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| Anthony Edwards | Inspector William Armstrong | |
| Chloë Sevigny | Melanie | |
| Brian Cox | Melvin Belli | |
| Mark Ruffalo | Inspector David Toschi | |
| Donal Logue | Captain Ken Narlow | |
| Dermot Mulroney | Captain Marty Lee | |
| Elias Koteas | Sgt. Jack Mulanax | |
| Richmond Arquette | Zodiac 1/Zodiac 2 | |
| Candy Clark | Carol Fisher | |
| John Terry | Charles Thieriot | |
| John Getz | Templeton Peck | |
| Jake Gyllenhaal | Robert Graysmith | |
| Robert Downey Jr. | Paul Avery | |
| Bob Stephenson | Zodiac 3 | |
| Ed Setrakian | Al Hyman |
| Director |
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| Productor | Mike Medavoy
Arnold Messer |
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| Escritor | James Vanderbilt
Robert Graysmith |
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| Fotografía | Harris Savides
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| Músicos | David Shire
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The true story of the investigation of the "Zodiac Killer", a serial killer who terrified the San Francisco Bay Area, taunting police with his ciphers and letters. The case becomes an obsession for four men as their lives and careers are built and destroyed by the endless trail of clues. |
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